Ridge preservation applying a novel hydrogel for early angiogenesis and osteogenesis evaluation: an experimental study in canine

Abstract Ridge preservation is universally acknowledged as the conventional method for post-extraction healing yet there are no standard materials ideal outcome. Herein, a composite gel comprising gelatin nanoparticles (GNPs) and injectable platelet-rich-fibrin (i-PRF) potential candidate extracted socket introduced. The combination of GNPs i-PRF not only possesses favorable mechanical properties to withstand external force but also accelerate blood clotting time significantly. In addition, six beagle dogs were adopted assess angiogenic osteogenic capacity GNPs+i-PRF in vivo. significantly produced most vessels area, woven bone low osteoclast activity sockets at 2 weeks postoperation remarkably generated corticalization on alveolar ridge crest 8 according histological results. Therefore, can be recommended grafting material regarding its cost effectiveness, excellent biocompatibility, facilitation promoting angiogenesis osteogenesis.